THE ROLE OF IMMUNO-BIOCHEMICAL MARKERS IN THE ACTIVE STAGE OF CHRONIC RHEUMATIC HEART DISEASE IN CHILDREN

Authors

  • Bobojonov Khurshid Jumaniyozovich Lecturer at the Department of Pre-Clinical Sciences Asia International University

DOI:

https://doi.org/10.5281/zenodo.20328942

Keywords:

heart disease

Abstract

Chronic rheumatic heart disease (CRHD) remains one of the most important acquired cardiovascular diseases in children and adolescents. The disease develops due to autoimmune inflammatory reactions after group A beta-hemolytic streptococcal infection and is characterized by progressive valvular damage, myocardial inflammation, and chronic cardiac insufficiency. The present study investigated serum levels of interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), and procalcitonin (PCT) in children with CRHD. Elevated TNF-α, CRP, and PCT together with reduced IL-10 were observed during active inflammatory stages. These biomarkers demonstrated high diagnostic and prognostic significance.

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Published

2026-05-21

Issue

Vol. 5 No. 5 (2026): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

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Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

THE ROLE OF IMMUNO-BIOCHEMICAL MARKERS IN THE ACTIVE STAGE OF CHRONIC RHEUMATIC HEART DISEASE IN CHILDREN. (2026). Journal of Multidisciplinary Sciences and Innovations, 5(5), 1547-1551. https://doi.org/10.5281/zenodo.20328942

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