MODULATION OF MYOCARDIAL COLLAGEN REMODELING BY MILK THISTLE AND SAFFLOWER EXTRACTS AFTER CARBON MONOXIDE EXPOSURE
DOI:
https://doi.org/10.55640/Keywords:
carbon monoxide, myocardium, collagen remodeling, fibrosis, Van Gieson staining, milk thistle, safflower, phytocorrection.Abstract
Carbon monoxide exposure causes tissue hypoxia and may lead to structural remodeling of the myocardium. One of the important manifestations of chronic myocardial injury is excessive collagen accumulation and development of interstitial fibrosis. The aim of this study was to evaluate collagen remodeling in the myocardium of white outbred rats after carbon monoxide exposure and to assess the corrective effect of milk thistle and safflower extracts. The study was performed on 6- and 18-month-old white outbred rats. Collagen fibers were detected using Van Gieson staining and assessed by digital morphometry.
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