DETECTION OF HPV 16/18 IN PATIENTS WITH PRECANCEROUS LESIONS OF THE ORAL MUCOSA

Authors

  • Alimukhamedova M.M.,Kakharova D.J. Tashkent State Medical University

DOI:

https://doi.org/10.55640/

Keywords:

human papillomavirus, HPV 16/18, precancerous diseases, oral mucosa, leukoplakia, PCR diagnostics, oncological alertness

Abstract

This article presents the results of a clinical and laboratory study devoted to evaluating the significance of detecting human papillomavirus (HPV) types 16 and 18 in patients with precancerous lesions of the oral mucosa. The relevance of the study is обусловлена the growing interest in the role of high-risk HPV types in oropharyngeal carcinogenesis and the need to improve early diagnosis of potentially malignant changes in dental practice. The study was carried out in 2024–2026 as an observational clinical investigation. A total of 20 patients aged 30 to 65 years with clinically diagnosed precancerous diseases of the oral mucosa were examined. All patients underwent clinical examination, assessment of complaints, recording of lesion localization and clinical form, as well as PCR-based HPV testing with genotyping for types 16 and 18. It was established that leukoplakia predominated in the structure of clinical forms, accounting for 60% of cases. The most frequent lesion localization was the lateral surface of the tongue (40%), followed by the buccal mucosa (25%) and the floor of the mouth (20%). HPV 16/18 DNA was detected in 2 out of 20 patients, which amounted to 10% of the study sample. The obtained data indicate that in the studied group HPV 16/18 was not the leading factor in the development of precancerous lesions; however, its detection has clinical significance as an additional criterion of oncological alertness and a basis for more careful follow-up observation. The study emphasizes the expediency of including PCR-based HPV typing in the comprehensive examination of patients with clinically suspicious lesions of the oral mucosa.

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References

1. Абдуллаходжаева М. и др. Особенности проявления и методы диагностики предраковых поражений слизистой оболочки полости рта // Stomatologiya. 2017. Т. 1. № 4(69). С. 18–19.

2. Адильбаев Г.Б. и др. Результаты исследования маркеров пролиферации Ki 67 и p16 у ВПЧ-ассоциированных и ВПЧ-негативных пациентов с раком полости рта и ротоглотки в Казахстане // Онкология и радиология Казахстана. 2023. № 2. С. 24–31.

3. Белякова Е.Н., Брико Н.И., Лопухов П.Д. Оценка знаний врачей-стоматологов о профилактике и раннем выявлении ассоциированного с вирусом папилломы человека рака головы и шеи // Инфекционные болезни: новости, мнения, обучение. 2021. Т. 10. № 2. С. 76–83.

4. Богатов В.В. и др. Роль вирусов с онкогенным потенциалом и их ассоциаций в генезе новообразований челюстно-лицевой области // Стоматология. 2015. Т. 94. № 1. С. 23–24.

5. Булгакова Н.Н., Волков Е.А., Позднякова Т.И. Аутофлуоресцентная стоматоскопия как метод онкоскрининга заболеваний слизистой оболочки рта // Российский стоматологический журнал. 2015. Т. 19. № 2. С. 37–40.

6. Волгарева Г.М. Папилломавирусный канцерогенез. Основные достижения и некоторые проблемы. Часть 1. Общие представления о папилломавирусах. Формы рака, ассоциированные с вирусами папилломы человека // Российский биотерапевтический журнал. 2020. Т. 19. № 3. С. 6–16.

7. Волгарева Г.М. Папилломавирусный канцерогенез. Основные достижения и некоторые проблемы. Часть 2. ВПЧ-ассоциированные формы рака в России. Профилактические ВПЧ-вакцины // Российский биотерапевтический журнал. 2020. Т. 19. № 4. С. 6–18.

8. Кирьянов Б.Н., Камилов Х.П. Современные аспекты диагностики и лечения заболеваний слизистой оболочки полости рта // Stomatologiya. 2020. № 4. С. 52–58.

9. Холопова Е.А., Фирсова И.В. Современные подходы к диагностике потенциально злокачественных заболеваний слизистой оболочки полости рта // Пародонтология. 2019. Т. 24. № 3. С. 15–22.

10. Warnakulasuriya S. Clinical features and presentation of oral potentially malignant disorders // Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2018. Vol. 125. No. 6. P. 582–590.

11. Warnakulasuriya S., Kujan O., Johnson N.W. Oral potentially malignant disorders: a consensus report from an international seminar on nomenclature and classification // Oral Diseases. 2021. Vol. 27. No. 8. P. 1862–1880.

12. El-Naggar A.K., Chan J.K.C., Grandis J.R., Takata T., Slootweg P.J. WHO Classification of Head and Neck Tumours. 4th ed. Lyon: IARC, 2017.

13. Kreimer A.R., Clifford G.M., Boyle P., Franceschi S. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review // Cancer Epidemiology, Biomarkers & Prevention. 2005. Vol. 14. No. 2. P. 467–475.

14. Gillison M.L., Chaturvedi A.K., Anderson W.F., Fakhry C. Epidemiology of human papillomavirus-positive head and neck squamous cell carcinoma // Journal of Clinical Oncology. 2015. Vol. 33. No. 29. P. 3235–3242.

15. Doorbar J. Molecular biology of human papillomavirus infection and cervical cancer // Clinical Science. 2006. Vol. 110. No. 5. P. 525–541.

16. Syrjänen S. Oral manifestations of human papillomavirus infections // European Journal of Oral Sciences. 2018. Vol. 126(S1). P. 49–66.

17. Viet C.T. et al. Artificial Intelligence Applications in Oral Cancer and Oral Dysplasia // Tissue Engineering Part A. 2024. Vol. 30. No. 19–20. P. 640–651.

18. Wang W., Sawleshwarkar S., Piraveenan M. Computational Approaches of Modelling Human Papillomavirus Transmission and Prevention Strategies: A Systematic Review // arXiv. 2024. arXiv:2404.19235.

19. Mehanna H. et al. Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer — systematic review and meta-analysis // The Lancet Oncology. 2013. Vol. 14. No. 8. P. 781–789.

20. Marur S., D’Souza G., Westra W.H., Forastiere A.A. HPV-associated head and neck cancer: a virus-related cancer epidemic // The Lancet Oncology. 2010. Vol. 11. No. 8. P. 781–789.

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Published

2026-03-12

Issue

Vol. 5 No. 03 (2026): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

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Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

DETECTION OF HPV 16/18 IN PATIENTS WITH PRECANCEROUS LESIONS OF THE ORAL MUCOSA. (2026). Journal of Multidisciplinary Sciences and Innovations, 5(03), 574-581. https://doi.org/10.55640/

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