SUBCLINICAL HYPOTHYROIDISM: WHEN SHOULD TREATMENT BE INITIATED?

Authors

  • G’ulomova Shahrinoz Qahramon kizi Department of Fundamental Medicine, Asia International University, Bukhara, Uzbekistan

DOI:

https://doi.org/10.55640/

Keywords:

subclinical hypothyroidism, TSH, levothyroxine, thyroid disorders, treatment indications.

Abstract

 Subclinical hypothyroidism (SCH) is a common endocrine disorder characterized by elevated serum thyroid-stimulating hormone (TSH) levels with normal circulating free thyroxine (fT4) concentrations. Despite its high prevalence, particularly among women and the elderly, the management of SCH remains controversial. While some patients progress to overt hypothyroidism or develop cardiovascular and metabolic complications, others remain stable or even revert to euthyroidism without intervention. Recent studies have produced conflicting results regarding the benefits of levothyroxine therapy, especially in mild forms of the disease. This review aims to summarize current knowledge on the epidemiology, pathophysiology, clinical implications, diagnostic approach, and treatment strategies of subclinical hypothyroidism, with a particular focus on identifying patients who may benefit from pharmacological intervention.

 

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References

1.Peeters RP, Razvi S. Subclinical hypothyroidism. Lancet Diabetes & Endocrinology. 2022;10(3):192–204.

2. Taylor PN, Razvi S, Pearce SHS, Dayan CM. Clinical review: A review of the clinical consequences of subclinical thyroid dysfunction. Journal of Clinical Endocrinology & Metabolism. 2020;105(12):dgaa672.

3.Rodondi N, Gussekloo J. Subclinical hypothyroidism in older adults. European Journal of Endocrinology. 2020;183(5):R185–R197.

4.Feller M, Moutzouri E, Bauer DC, et al. Levothyroxine therapy for older adults with subclinical hypothyroidism. New England Journal of Medicine. 2020;382(26):2494–2503.

5.Kahapola-Arachchige KM, Hadlow NC, Wardrop R, Lim EM, Walsh JP. Age-specific TSH reference ranges and implications for diagnosis of subclinical hypothyroidism. Clinical Endocrinology. 2021;95(1):87–96.

6.Gencer B, Collet TH, Virgini V, et al. Thyroid function and cardiovascular outcomes: new insights. European Heart Journal. 2021;42(23):2267–2275.

7.Duntas LH, Jonklaas J. Levothyroxine therapy in subclinical hypothyroidism: new evidence and remaining questions. Nature Reviews Endocrinology. 2021;17(12):725–736.

8.Negro R, Stagnaro-Green A. Diagnosis and management of subclinical hypothyroidism in pregnancy. BMJ. 2021;373:n1159.

9.Iodine deficiency, thyroid function and subclinical hypothyroidism. European Thyroid Journal. 2022;11(1):e210046.

10. Pearce SHS, Brabant G, Duntas LH, et al. 2023 European Thyroid Association clinical practice guideline for the management of subclinical hypothyroidism. European Thyroid Journal. 2023;12(3):e220146.

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Published

2026-02-23

Issue

Vol. 5 No. 02 (2026): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

SUBCLINICAL HYPOTHYROIDISM: WHEN SHOULD TREATMENT BE INITIATED?. (2026). Journal of Multidisciplinary Sciences and Innovations, 5(02), 1908-1911. https://doi.org/10.55640/

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