NEUROPROTECTION IN NEWBORNS WITH HYPOXIC–ISCHEMIC ENCEPHALOPATHY
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Abstract
Hypoxic–ischemic encephalopathy (HIE) is a severe neurological condition in newborns resulting from impaired cerebral blood flow and oxygen deprivation during the perinatal period. It remains one of the leading causes of neonatal mortality and long-term neurodevelopmental disability worldwide. Neuroprotective strategies aim to reduce secondary brain injury and improve neurological outcomes in affected infants. This article analyzes the mechanisms of hypoxic–ischemic brain damage and evaluates current neuroprotective approaches used in newborns with HIE. Particular attention is given to therapeutic hypothermia, pharmacological neuroprotection, and supportive care strategies. Early diagnosis and timely initiation of neuroprotective interventions are critical for optimizing neurodevelopmental outcomes.
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References
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