NEUROPROTECTION IN NEWBORNS WITH HYPOXIC–ISCHEMIC ENCEPHALOPATHY

Authors

  • Azimova Irodaxon Azizbek qizi,Muhammadjonova Durdona Muhammadjonovna Master’s Student, Andijan State Medical Institute, Andijan, Uzbekistan Scientific Supervisor, PhD, Associate Professor, Andijan State Medical Institute, Andijan, Uzbekistan

DOI:

https://doi.org/10.55640/

Keywords:

Hypoxic–ischemic encephalopathy, newborns, neuroprotection, therapeutic hypothermia, neonatal brain injury, neurodevelopmental outcomes

Abstract

Hypoxic–ischemic encephalopathy (HIE) is a severe neurological condition in newborns resulting from impaired cerebral blood flow and oxygen deprivation during the perinatal period. It remains one of the leading causes of neonatal mortality and long-term neurodevelopmental disability worldwide. Neuroprotective strategies aim to reduce secondary brain injury and improve neurological outcomes in affected infants. This article analyzes the mechanisms of hypoxic–ischemic brain damage and evaluates current neuroprotective approaches used in newborns with HIE. Particular attention is given to therapeutic hypothermia, pharmacological neuroprotection, and supportive care strategies. Early diagnosis and timely initiation of neuroprotective interventions are critical for optimizing neurodevelopmental outcomes.

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References

1.Volpe, J. J. (2018). Neurology of the Newborn. Elsevier.

2.Shankaran, S., et al. (2005). Whole-body hypothermia for neonates with hypoxic–ischemic encephalopathy. New England Journal of Medicine, 353(15), 1574–1584.

3.Jacobs, S. E., et al. (2013). Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database of Systematic Reviews, (1), CD003311.

4.Robertson, N. J., et al. (2012). Therapeutic hypothermia for neonatal hypoxic–ischemic encephalopathy. Archives of Disease in Childhood, 97(4), 362–368.

5.Juul, S. E., & Ferriero, D. M. (2014). Pharmacologic neuroprotective strategies in neonatal brain injury. Clinical Perinatology, 41(1), 119–131.

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Published

2026-01-20

Issue

Vol. 5 No. 01 (2026): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

NEUROPROTECTION IN NEWBORNS WITH HYPOXIC–ISCHEMIC ENCEPHALOPATHY. (2026). Journal of Multidisciplinary Sciences and Innovations, 5(01), 1341-1344. https://doi.org/10.55640/

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