PECULIAR FEATURES OF THE IMMUNE SYSTEM AND ADAPTATION MECHANISMS DURING PREGNANCY

Authors

  • Tursunova Husnida Yoldashali kizi Kokand University, Andijan branch, Faculty of medicine, General medicine
  • Soliyeva Ummu Gulsum Abdulvosid kizi Kokand University, Andijan branch, Faculty of medicine, General medicine
  • Mirzayeva Saidaxon Abdusalomovna Professor of the department of Microbiology, Virology and Immunology, Kokand University, Andijan branch, Scientific supervisor

DOI:

https://doi.org/10.55640/

Keywords:

pregnancy, immune system, immune tolerance, cellular immunity, humoral immunity, cytokines, placenta, hormones.

Abstract

Pregnancy is a complex physiological process occurring in the female body, during which significant changes take place in the functioning of the immune system. The maternal organism must simultaneously maintain sufficient protection against infectious agents while preserving the genetically foreign fetus. This article provides a scientific analysis of the specific features of the immune system during pregnancy, adaptation mechanisms of innate and adaptive immunity, changes in cellular and humoral immune responses, cytokine balance, the influence of hormonal factors on the immune system, and the immunological role of the fetoplacental complex. The results of the study demonstrate that the formation of immune tolerance mechanisms during pregnancy plays a crucial role in ensuring maternal and fetal health. This article is intended for medical university students, master’s students, researchers, and practicing physicians.

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References

1. Abdukarimov, A. A. (2018). Fundamentals of Immunology. Tashkent: Abu Ali ibn Sina Medical Institute Publishing House. https://tma.uz/immunologiya_asoslari.pdf

2. Karimova, M. S. (2019). Immune adaptation mechanisms during pregnancy. Medical Journal, 3(2), 45–52. https://journal.med.uz/article123

3. Yoldoshev, D. A. (2018). Human Physiology. Tashkent: Fan va Texnologiya Publishing House. https://ziyonet.uz/fiziologiya.pdf

4. Ismoilova, N. N. (2017). Cytokines and their biological significance. Problems of Biology and Medicine, 4, 33–38. https://biomed.uz/sitokinlar.pdf

5. Tursunova, G. M. (2019). The effect of hormonal changes on the immune system. Endocrinology Bulletin, 1, 56–61. https://endo.uz/gormon_immun.pdf

6. Khudoyberdiyev, S. S. (2021). Immunological functions of the placenta. Perinatology, 2(1), 21–27. https://perinatal.uz/article45

7. Rakhimov, B. R. (2020). Obstetrics and Gynecology. Tashkent: National Encyclopedia of Uzbekistan Publishing House. https://library.uz/akusherlik.pdf

8. Rasulov, K. K. (2020). Immunological aspects of pregnancy complications. Science and Medicine, 5, 14–20. https://science-med.uz/maqola78

9. Ministry of Health of the Republic of Uzbekistan. (2022). Clinical Guidelines on Obstetrics. https://ssv.uz/akusherlik_tavsiyalar.pdf1. Abdukarimov, A. A. (2018). Fundamentals of Immunology. Tashkent: Abu Ali ibn Sina Medical Institute Publishing House. https://tma.uz/immunologiya_asoslari.pdf

2. Karimova, M. S. (2019). Immune adaptation mechanisms during pregnancy. Medical Journal, 3(2), 45–52. https://journal.med.uz/article123

3. Yoldoshev, D. A. (2018). Human Physiology. Tashkent: Fan va Texnologiya Publishing House. https://ziyonet.uz/fiziologiya.pdf

4. Ismoilova, N. N. (2017). Cytokines and their biological significance. Problems of Biology and Medicine, 4, 33–38. https://biomed.uz/sitokinlar.pdf

5. Tursunova, G. M. (2019). The effect of hormonal changes on the immune system. Endocrinology Bulletin, 1, 56–61. https://endo.uz/gormon_immun.pdf

6. Khudoyberdiyev, S. S. (2021). Immunological functions of the placenta. Perinatology, 2(1), 21–27. https://perinatal.uz/article45

7. Rakhimov, B. R. (2020). Obstetrics and Gynecology. Tashkent: National Encyclopedia of Uzbekistan Publishing House. https://library.uz/akusherlik.pdf

8. Rasulov, K. K. (2020). Immunological aspects of pregnancy complications. Science and Medicine, 5, 14–20. https://science-med.uz/maqola78

9. Ministry of Health of the Republic of Uzbekistan. (2022). Clinical Guidelines on Obstetrics. https://ssv.uz/akusherlik_tavsiyalar.pdf

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Published

2025-12-18

Issue

Vol. 4 No. 11 (2025): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

PECULIAR FEATURES OF THE IMMUNE SYSTEM AND ADAPTATION MECHANISMS DURING PREGNANCY. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(11), 2424-2427. https://doi.org/10.55640/

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