EVALUATING THE EFFICACY OF BETA-BLOCKER THERAPY IN CHILDREN WITH HEART FAILURE
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English: Heart failure (HF) in children, while less common than in adults, is a serious condition with significant morbidity and mortality, often resulting from congenital heart defects or cardiomyopathy. The pathophysiology involves sustained neurohormonal activation, particularly of the sympathetic nervous system, which leads to progressive cardiac remodeling and dysfunction. In adult HF, beta-adrenergic receptor blockers (beta-blockers) are a cornerstone of therapy, proven to improve cardiac function and survival. However, the pediatric HF population is heterogeneous, and the underlying causes differ significantly from adults. Therefore, directly extrapolating adult treatment guidelines is not always appropriate. Investigating the specific efficacy, safety, and optimal use of beta-blockers in children with HF is crucial for developing evidence-based pediatric treatment protocols and improving clinical outcomes in this vulnerable population. This expanded review seeks to provide a deeper analysis of the existing evidence, challenges in clinical application, and future research directions.
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