GUTTERS' MICROBIOTA IN CHILDREN: ITS ROLE IN IMMUNITY DEVELOPMENT AND THE RELATIONSHIP BETWEEN DYSBIOSIS AND ALLERGIC AND AUTOIMMUNE DISEASES

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Published: 2025-10-08
DOI: https://doi.org/10.55640/
Keywords:
intestinal microbiota, children, immunity, dysbiosis, allergies, autoimmune diseases, probiotics.

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Makhamedova Saodat,Nafasova Saodat Nadir Kizi,Abdukadirova M.K.
Second-year Student, Faculty of Pediatrics Tashkent International Kime University,Second-year Student, Faculty of Pediatrics Tashkent International Kime University,Scientific Supervisor, Assistant Professor, Department of Neonatology, Tashkent State Medical University

Abstract

Gut microbiota significantly influences the development and functioning of a child's immune system. From the first days of life, the gut microbiota plays an active role in the development of innate and acquired immunity, promoting immune tolerance and protecting the body from infectious agents. Alterations in the composition of the intestinal microflora, or dysbiosis, weaken the barrier function of the mucosa and can cause immune imbalances. This paper examines the fundamental mechanisms of interaction between the microbiota and the immune system, as well as the relationship between dysbiotic changes and the development of allergic (e.g., atopic dermatitis, bronchial asthma) and autoimmune diseases (such as type 1 diabetes mellitus and celiac disease). Particular attention is paid to modern methods of preventing and correcting dysbiosis in children, including breastfeeding, the use of probiotics, and the rational use of antibacterial agents.

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Vol. 4 No. 9 (2025): Journal of Multidisciplinary Sciences and Innovations

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

GUTTERS’ MICROBIOTA IN CHILDREN: ITS ROLE IN IMMUNITY DEVELOPMENT AND THE RELATIONSHIP BETWEEN DYSBIOSIS AND ALLERGIC AND AUTOIMMUNE DISEASES. (2025). Journal of Multidisciplinary Sciences and Innovations, 4(9), 161-170. https://doi.org/10.55640/

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