PREGNANCY, LABOR, AND PERINATAL OUTCOMES IN PREGNANT WOMEN WITH HEPATITIS C VIRUS INFECTION
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Hepatitis C virus (HCV) infection in pregnancy presents unique challenges in maternal and perinatal care. This prospective, multicenter observational study evaluates the impact of maternal HCV infection on pregnancy outcomes, labor complications, and perinatal results. A total of 550 pregnant women, including 220 HCV-positive and 330 HCV-negative controls, were enrolled from January 2019 to December 2021. Data were collected on maternal demographics, pregnancy complications, mode of delivery, and neonatal outcomes. The HCV-positive group exhibited a significantly higher rate of gestational diabetes, preterm delivery, and intrahepatic cholestasis of pregnancy (ICP). Additionally, adverse perinatal outcomes, including lower birth weights and increased neonatal intensive care unit (NICU) admissions, were observed in the HCV-positive cohort. Multivariate analysis confirmed maternal HCV infection as an independent risk factor for preterm birth (OR 2.1, 95% CI 1.4–3.2, p < 0.001) and low birth weight (OR 1.8, 95% CI 1.2–2.7, p = 0.004). These findings underscore the importance of targeted antenatal surveillance and intervention in HCV-positive pregnancies to improve maternal and neonatal outcomes [1].
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References
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