PREGNANCY, LABOR, AND PERINATAL OUTCOMES IN PREGNANT WOMEN WITH HEPATITIS C VIRUS INFECTION
Abstract
Hepatitis C virus (HCV) infection in pregnancy presents unique challenges in maternal and perinatal care. This prospective, multicenter observational study evaluates the impact of maternal HCV infection on pregnancy outcomes, labor complications, and perinatal results. A total of 550 pregnant women, including 220 HCV-positive and 330 HCV-negative controls, were enrolled from January 2019 to December 2021. Data were collected on maternal demographics, pregnancy complications, mode of delivery, and neonatal outcomes. The HCV-positive group exhibited a significantly higher rate of gestational diabetes, preterm delivery, and intrahepatic cholestasis of pregnancy (ICP). Additionally, adverse perinatal outcomes, including lower birth weights and increased neonatal intensive care unit (NICU) admissions, were observed in the HCV-positive cohort. Multivariate analysis confirmed maternal HCV infection as an independent risk factor for preterm birth (OR 2.1, 95% CI 1.4–3.2, p < 0.001) and low birth weight (OR 1.8, 95% CI 1.2–2.7, p = 0.004). These findings underscore the importance of targeted antenatal surveillance and intervention in HCV-positive pregnancies to improve maternal and neonatal outcomes [1].
Keywords
Hepatitis C, pregnancy outcomes, perinatal outcomes, preterm delivery, intrahepatic cholestasis, neonatal intensive careHow to Cite
References
1.World Health Organization. (2017). Global Hepatitis Report 2017. WHO Press.
2.Chen, C. C., Lin, S. M., et al. (2018). “Maternal hepatitis C virus infection and pregnancy outcomes: A nationwide population-based cohort study.” Journal of Hepatology, 68(3), 491–498.
3.Mahale, P., Redd, A. D., et al. (2019). “Adverse perinatal outcomes in women with hepatitis C: A systematic review and meta-analysis.” Obstetrics & Gynecology, 134(3), 574–582.
4.Абдукодиров, Ш. Т. "ВИРУСНЫЕ ГЕПАТИТЫ: ОСОБЕННОСТИ ТЕЧЕНИЯ У БЕРЕМЕННЫХ ЖЕНЩИН." In Russian-Uzbekistan Conference, vol. 1, no. 1. 2024.
5.Mirzakarimova, D. B., G. M. Hodjimatova, and S. T. Abdukodirov. "FEATURES OF PATHOGENESIS, CLINICAL PICTURE AND DIAGNOSIS OF CO-INFECTION OF THE LIVER WITH HEPATITIS B AND C VIRUSES." International Multidisciplinary Journal for Research & Development 11, no. 02 (2024).
6.Restrepo, S., et al. (2020). “Impact of chronic hepatitis C on obstetric and perinatal outcomes.” Clinical Infectious Diseases, 71(7), 1760–1766.
7.American College of Obstetricians and Gynecologists. (2021). Practice Bulletin: Management of Hepatitis C in Pregnancy. ACOG.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.
