EVALUATION AND DETERMINATION OF PSYCHOTROPIC ACTIVITY OF SOME INDOLE ALKALOIDS
Main Article Content
Abstract
Nootropic activity of indole flavonoids, including pyrazolone and pyrazolone chloride, during the action of stimuli causing sleep and fear induced by alcohol was studied using the Sonberg method. In this study, pyrazoline and pyrazoline chloride reduced sleep time by increasing the sleep time induced by alcohol, while in the Sonberg method, the excretion of urine and feces in experimental animals was reduced under the influence of noise and external factors. This suggests that the studied substances have a calming effect.
Downloads
Article Details
Section

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.
How to Cite
References
1. Study of physicochemical and technological properties of the substance pyrazoline hydrochloride // Universum: technical sciences: electronic. scientific journal. Rakhimova O.R. [et al.]. 2021. 9(90). URL: https://7universum.com/ru/tech/archive/item/12260
2. Abduazimov B.B., Adizov Sh.M., Mirzaev Yu.R., Yuldashev P.Kh. Khamroev T.T. Elements of the psychopharmacological action of pyrazoline chloride. Actual problems of the chemistry of natural compounds, scientific and practical conference of young scientists dedicated to the 110th anniversary of academician S.Yu.Yunusov 2019.124.
3.Mirzaev Yu.R., Khamroev T.T., Ruzimov E.M., Khamdamov B.N., Abduazimov B.B., Adizov Sh.M., Yuldashev P.Kh., & Elmuradov B.J. (2022). Comparative assessment of acute toxicity of vincanin hydrochloride derivatives in research conditions. International Journal of Medical Sciences and Clinical Research, 2(10), 9–15. https://doi.org/10.37547/ijmscr/Volume02Issue10-03
4.Mirzaev Yu.R., Khamraev T.T., Ruzimov E.M., Khandamov B.N., Abduazimov B.B., Adizov Sh.M., Elmurodov B.J., Yuldashev P.H.. (2022). Study of the effect of alkaloids isolated from the vinca erecta plant on cardiac activity under experimental conditions. Eurasian journal of medical and natural sciences, 2(11),250–255. https://doi.org/10.5281/zenodo.7220861
5.Yu.R. Mirzaev, T.T. Khamroev, E.M. Ruzimov, B.N. Khandamov, B.B. Abduazimov, Sh.M. Adizov, P.Kh. Yuldashev, & B.J. Elmuradov. (2022). Evaluation of the effect of vincanin hydrochloride and its derivatives on blood pressure and respiration under experimental conditions. Oriental Journal of Medicine and Pharmacology, 2(04), 1–11. https://doi.org/10.37547/supsci-ojmp-02-04-01
6. Mironov A.N. Guidelines for conducting preclinical studies of drugs. Part one. - M. Grif i K, 2012. - 944 p.
7. Instructions for preclinical testing of pharmacological agents. Tashkent - 2000
8. Khabriev R.U. (Ed.). Guidelines for experimental (preclinical) study of new pharmacological substances. Moscow. 2005, p.832.
9. Preclinical toxicological study of new substances, including antitumor ones, conducted in accordance with the requirements of the Pharmacological Committee of the USSR Ministry of Health, Moscow, 1976
10. European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes, ETS No. 123, Strasbourg (1986).
11. Belenkiy M.L. Elements of quantitative assessment of pharmacological effect. - L., "Gosmetizdat", 1963. - 151 p.
12. Strelkov R.B. Statistical tables for accelerated quantitative assessment of pharmacological effect. Pharmacology and toxicology 1986. No. 4 p. 100-104.