THE ROLE OF INFLAMMATORY BIOMARKERS IN THE EARLY DIAGNOSIS OF SEPSIS
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Abstract
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, leading to organ dysfunction. Early diagnosis is essential to improve patient outcomes, and inflammatory biomarkers have emerged as key tools in identifying sepsis in its early stages. This article reviews the clinical significance, diagnostic value, and limitations of biomarkers such as C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6), and others in the early detection of sepsis. Understanding the utility and interpretation of these markers helps clinicians make faster and more accurate decisions in critical care settings.
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1.Angus, D. C., & van der Poll, T. (2013). Severe sepsis and septic shock. The New England Journal of Medicine, 369(9), 840–851. https://doi.org/10.1056/NEJMra1208623
2.Wacker, C., Prkno, A., Brunkhorst, F. M., & Schlattmann, P. (2013). Procalcitonin as a diagnostic marker for sepsis: A systematic review and meta-analysis. The Lancet Infectious Diseases, 13(5), 426–435. https://doi.org/10.1016/S1473-3099(12)70323-7
3.Luzzani, A., Polati, E., Dorizzi, R., Rungatscher, A., Pavan, R., & Merlini, A. (2003). Comparison of procalcitonin and C-reactive protein as markers of sepsis. Critical Care Medicine, 31(6), 1737–1741. https://doi.org/10.1097/01.CCM.0000065280.93510.B2
4.Sobirjonovich, S. I. (2023). Systemic Organization of Professional Competence, Creativity and Innovative Activity of A Future Kindergartener. Journal of Pedagogical Inventions and Practices, 19, 108-112.
5.Abdurashidov, A., & Turdaliyeva, N. (2023). DEVELOPMENT OF MANUAL WORK IN PRE-SCHOOL EDUCATION. Science and innovation, 2(B2), 282-286.
6.Mukhamedova, M. G., Kurtieva, Sh. A., & Nazarova, Zh. A. (2020). FUNCTIONAL CARDIOPATHY SYNDROME IN MODERN ADOLESCENTS. In P84 Preventive Medicine-2020: collection of scientific papers of the All-Russian scientific and practical conference with international participation. November 18-19, 2020 / edited by A. V. Meltzer, I. Sh. Yakubova. Part 2. - St. Petersburg: Publishing house of North-Western State Medical University named after I. I. Mechnikov, 2020. - 304 p. (p. 105)Meisner, M. (2010). Update on procalcitonin measurements. Annals of Laboratory Medicine, 30(2), 121–130. https://doi.org/10.3343/alm.2010.30.2.121
7.Pierrakos, C., & Vincent, J.-L. (2010). Sepsis biomarkers: A review. Critical Care, 14(1), R15. https://doi.org/10.1186/cc8872
8.Tan, M., Lu, Y., Jiang, H., & Zhang, L. (2014). The diagnostic accuracy of procalcitonin and C-reactive protein for sepsis: A systematic review and meta-analysis. Journal of Cellular