DIAGNOSTIC SIGNIFICANCE OF BIOMARKERS (CA-125, HE4) IN OVARIAN CANCER SCREENING

Authors

  • Khurramova Zahro Uktam kizi Student of group 225-A, 2nd Faculty of General Medicine, Tashkent State Medical Academy.
  • Zulfikariyev Diyorbek Davronbekovich Senior Lecturer, Department of Medical Radiology No

DOI:

https://doi.org/10.55640/

Keywords:

ovarian cancer, CA-125, HE4, ROMA index, biomarker, screening. Introduction (Fragment):

Abstract

This article analyzes the diagnostic significance of CA-125 and HE4 biomarkers in the early detection of ovarian cancer (OC). Research indicates that while CA-125 is a classic marker, its sensitivity in the early stages and specificity regarding benign tumors are relatively low. In contrast, the HE4 biomarker is distinguished by the fact that its levels do not rise in gynecological conditions such as endometriosis. The ROMA index, which integrates these two markers with the patient’s menopausal status, provides the highest accuracy (sensitivity ~90%) in diagnosing ovarian cancer.

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References

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Published

2026-05-05

Issue

Vol. 5 No. 5 (2026): Journal of Multidisciplinary Sciences and Innovations

Section

Articles

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

DIAGNOSTIC SIGNIFICANCE OF BIOMARKERS (CA-125, HE4) IN OVARIAN CANCER SCREENING. (2026). Journal of Multidisciplinary Sciences and Innovations, 5(5), 303-307. https://doi.org/10.55640/

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