CHEMICAL-TOXICOLOGICAL ANALYSIS OF PREGABALIN (LYRICA) IN BIOLOGICAL FLUIDS USING A GAS CHROMATOGRAPH (CRYSTALLUX-4000M)

Authors

  • Khusanov Azamat Sotivoldievich x

DOI:

https://doi.org/10.55640/

Keywords:

Pregabalin, Lyrica, gas chromatography, CrystalLux-4000M, biological fluids, toxicological analysis, forensic chemistry.

Abstract

This article presents a detailed methodological approach to the chemical-toxicological analysis of pregabalin (commercially known as Lyrica) in biological fluids using the gas chromatographic system CrystalLux-4000M. Due to pregabalin’s increasing misuse and inclusion in the list of psychotropic substances in many countries, the need for precise, sensitive, and reliable analytical methods is more pressing than ever. The article describes the procedures for sample preparation, extraction techniques, chromatographic conditions, and identification parameters for pregabalin in fluids such as blood plasma and urine. It also highlights the analytical advantages of the CrystalLux-4000M, particularly its thermal stability, high resolution, and applicability in forensic and clinical toxicology.

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References

1.Musshoff, F., & Madea, B. (2019). Pregabalin: Drug of abuse and its detection. Forensic Science International, 301, 1–9.

2.El-Gindy, A., Emara, S., & Shaaban, H. (2016). Development of a GC method for determination of pregabalin in human plasma. Journal of Chromatographic Science, 54(5), 873–880.

3.Ashraf, A., & Hammad, M. (2020). Toxicological screening of antiepileptic drugs in biological fluids using GC-MS. Toxicology Reports, 7, 215–221.

4.Manufacturer’s Manual. Gas Chromatograph CrystalLux-4000M: Technical Specifications and Applications. Chromatek, 2018.

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Published

2025-04-21

Issue

Vol. 4 No. 3 (2025): Journal of Multidisciplinary Sciences and Innovations: Journal of Multidisciplinary Sciences and Innovations

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors retain the copyright of their manuscripts, and all Open Access articles are disseminated under the terms of the Creative Commons Attribution License 4.0 (CC-BY), which licenses unrestricted use, distribution, and reproduction in any medium, provided that the original work is appropriately cited. The use of general descriptive names, trade names, trademarks, and so forth in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations.

How to Cite

CHEMICAL-TOXICOLOGICAL ANALYSIS OF PREGABALIN (LYRICA) IN BIOLOGICAL FLUIDS USING A GAS CHROMATOGRAPH (CRYSTALLUX-4000M). (2025). Journal of Multidisciplinary Sciences and Innovations, 4(3), 511-512. https://doi.org/10.55640/

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