INTERRELATION BETWEEN VITAMIN D DEFICIENCY AND SOMATIC COMPLICATIONS IN CHRONIC PANCREATITIS
DOI:
https://doi.org/10.55640/Keywords:
chronic pancreatitis, vitamin D, vitamin D deficiency, pathogenesis, laboratory diagnostics, somatic risks, osteoporosis, inflammation, metabolic disorders.Abstract
Chronic pancreatitis (CP) represents a progressive inflammatory disease of the pancreas, characterized by irreversible morphological changes and persistent impairment of its exocrine and endocrine functions. One of the critical metabolic disturbances associated with CP is malabsorption of essential nutrients, particularly fat-soluble vitamins such as vitamin D. Owing to the exocrine insufficiency of the pancreas, patients with CP frequently develop vitamin D deficiency, which significantly exceeds that observed in the general population. This deficiency contributes to a range of systemic complications, including disorders of calcium-phosphorus metabolism, osteopenia, osteoporosis, muscle weakness, cardiovascular dysfunction, and increased susceptibility to infectious diseases.
The present review provides an in-depth analysis of the pathophysiological mechanisms linking vitamin D deficiency to chronic pancreatitis, emphasizing its role in inflammation modulation, immune regulation, and bone metabolism. Special attention is given to current laboratory diagnostic methods for assessing vitamin D status, including the measurement of serum 25(OH)D concentrations, and the interpretation of these findings within the context of somatic comorbidities. Furthermore, the review highlights the clinical importance of early detection, monitoring, and correction of vitamin D deficiency as a preventive and therapeutic strategy aimed at reducing disease burden, improving musculoskeletal and metabolic outcomes, and enhancing the overall quality of life in patients with chronic pancreatitis.
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