INFLAMMATION AS A CENTRAL PATHOPHYSIOLOGICAL MECHANISM IN HUMAN DISEASES
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Abstract
Inflammation is a fundamental biological response to harmful stimuli such as infection, tissue injury, and toxins. While acute inflammation serves as a protective mechanism, uncontrolled or chronic inflammation contributes to the pathogenesis of a wide range of diseases including cardiovascular disorders, autoimmune conditions, cancer, and neurodegeneration. This paper explores the molecular and cellular mechanisms of inflammation, its dual role in health and disease, and its significance as a therapeutic target. Through a systematic review of experimental and clinical studies, the study highlights how dysregulated inflammatory pathways can transform a protective response into a driving force of chronic pathology.
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1.Medzhitov, R. (2021). Inflammation: Causes and consequences. Immunity, 54(3), 437–450.
2.Xoldarova, N. (2025). A PSYCHOLINGUISTIC APPROACH TO GRADUONYMY PHENOMENA IN THE LEXICAL AND SEMANTIC LEVELS OF ENGLISH AND UZBEK. Journal of Applied Science and Social Science, 1(1), 652-659.
3.Кузиева, С. У., & Ишонкулова, Д. У. (2018). ВЫДЕЛЕНИЕ И ЭЛЕКТРОФОРЕТИЧЕСКИЕ СВОЙСТВА МАЛАТДЕГИДРОГЕНАЗЫ ХЛОПЧАТНИКА. In INTERNATIONAL SCIENTIFIC REVIEW OF THE PROBLEMS AND PROSPECTS OF MODERN SCIENCE AND EDUCATION (pp. 14-16).
4.Zawacki-Richter, O., Marín, V. I., Bond, M., & Gouverneur, F. (2019). Systematic review of research on artificial intelligence applications in higher education. International Journal of Educational Technology in Higher Education, 16(1), 39.
5.Mukhamedova, M., Orziev, D. Z., Uzokov, J. K., & Abdullaev, A. X. (2023). Optimization of antiplatelet therapy in patients with coronary artery disease and type 2 diabetes mellitus after percutaneous coronary interventions. European Journal of Cardiovascular Nursing, 22(Supplement_1), zvad064-111.
6.Xoldarova, N. (2025). THE ROLE OF GRADUONYMY IN THE LEXICAL AND SEMANTIC LEVELS OF ENGLISH AND UZBEK: A PSYCHOLINGUISTIC VIEW. International Journal of Artificial Intelligence, 1(1), 1173-1178.
7.UNESCO. (2023). Guidelines on the Ethics of Artificial Intelligence in Education. Paris: UNESCO Publishing.
8.Мухамедова, М. Г., Куртиева, Ш. А., & Назарова, Ж. А. (2020). СИНДРОМ ФУНКЦИОНАЛЬНОЙ КАРДИОПАТИИ У СОВРЕМЕННЫХ ПОДРОСТКОВ. In П84 Профилактическая медицина-2020: сборник научных трудов Все-российской научно-практической конференции с международным участи-ем. 18–19 ноября 2020 года/под ред. АВ Мельцера, ИШ Якубовой. Ч. 2.—СПб.: Изд-во СЗГМУ им. ИИ Мечникова, 2020.—304 с. (p. 105).
9.Kuzieva, S. U., Imomova, D. A., & Abduraimov, O. S. (2020). Ontogenetic Structure Cenopopulations of Spiraea hypericifolia L. in Turkestan Ridge (Uzbekistan). Архив Научных Публикаций JSPI.
10. Holmes, W., Bialik, M., & Fadel, C. (2019). Artificial Intelligence in Education: Promises and Implications for Teaching and Learning. Boston: Center for Curriculum Redesign.
11. Mukhamedova, M., Alyavi, B. A., Uzokov, J. K., Babaev, M. A., & Kamilova, S. E. (2019). P120 Relationship between left ventricular global function index and cardiac systolic functions in patients with chronic ischemic disease of the heart and diabetes mellitus. European Heart Journal-Cardiovascular Imaging, 20(Supplement_3), jez147-008.